DOWNSLOPING HIGH-FREQUENCY HEARING LOSS DUE TO INNER EAR TRICELLULAR TIGHT JUNCTION DISRUPTION BY A NOVEL ILDR1 MUTATION IN THE IG-LIKE DOMAIN.

Downsloping high-frequency hearing loss due to inner ear tricellular tight junction disruption by a novel ILDR1 mutation in the Ig-like domain.

The immunoglobulin (Ig)-like domain containing receptor 1 (ILDR1) gene encodes angulin-2/ILDR1, a recently discovered tight junction protein, which forms tricellular tight junction (tTJ) structures with tricellulin and lipolysis-stimulated lipoprotein receptor (LSR) at tricellular contacts (TCs) in the inner ear.Previously reported recessive mutati

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Operational Stability of Hydropower Plant with Upstream and Downstream Surge Chambers during Small Load Disturbance

A surge chamber is a common pressure reduction facility in a hydropower plant.Owing to large flow inertia in the upstream headrace tunnel and downstream tailrace tunnel, a hydropower plant with upstream and downstream surge chambers (HPUDSC) was adopted.This paper aimed to investigate the operational stability and Boxes nonlinear dynamic behavior o

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Erythropoietin couples hematopoiesis with bone formation.

It is well established that bleeding activates the hematopoietic system to regenerate the loss of mature blood elements.We have shown that hematopoietic stem cells (HSCs) isolated from animals challenged with an acute bleed regulate osteoblast differentiation from marrow stromal cells.This suggests that HSCs participate in bone formation where the

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Integrative Analysis of Transcriptome and Metabolome Sheds Light on Flavonoid Biosynthesis in the Fruiting Body of Stropharia rugosoannulata

Flavonoids are a diverse family of natural compounds that are widely distributed in plants and play a critical role in plant growth, development, and stress adaptation.In recent years, the biosynthesis of flavonoids in plants has been well-researched, with the successive discovery of key genes driving this process.However, the regulation of flavono

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